10 Influential Rap Songs from the 2000s That Changed the Game

The 2000s marked a golden era in hip-hop, where rap songs incorporated storytelling, evocative lyrics, and pure creativity. These influential rap songs from the 2000s didn’t just soundtrack a decade; they reshaped the genre and culture. Each one pushed creative boundaries and left an undeniable mark on hip-hop history.

Beginning from street tales to club anthems and emotional confessionals, the decade produced influential tracks that not only ruled the charts but redefined what rap could be. Here are 10 rap songs from the 2000s that didn’t just make waves, but also became landmarks in hip-hop history.

10 Influential Rap Songs from the 2000s That Define Hip-Hop

1. “Lose Yourself” – Eminem (2002)

   
   Written for the 8 Mile soundtrack, this track captures the tension and adrenaline of seizing a once-in-a-lifetime opportunity. It quickly became fans favorite because of Eminem’s raw delivery and motivational lyrics, making it connect with audiences globally. It dominated the charts, holding the #1 spot on Billboard for 12 weeks and becoming the first rap song to win an Academy Award for Best Original Song.

Fun fact: Surprisingly, Em scribbled parts of the chorus on scraps of paper between filming scenes for 8 Mile. Who knew it would end up becoming a global anthem?

2. “Jesus Walks” – Kanye West (2004)

   
   This track proved that spiritual content could live on mainstream radio. Kanye West took a bold risk by centering a rap song around faith and the struggle for redemption. It peaked at #11 on the Billboard Hot 100 and won a Grammy for Best Rap Song.
   Fun fact: Kanye even released three different music videos to ensure his message wasn’t ignored. Thrice a charm!

2. “99 Problems” – Jay-Z (2003)

   
   This track infused rock elements with Jay-Z’s lyrical finesse and was produced by Rick Rubin, Def Jam Recordings co-founder. The second verse, recounting a real-life traffic stop, became iconic for its social commentary. 

Fun fact: Interestingly, the title phrase was inspired by a line from Ice-T. Weird? Well, it also wasn’t crafted as a commercial single; it became one of The Black Album‘s biggest moments. 

4. “In Da Club” – 50 Cent (2003)

   
   50 Cent burst onto the scene with this Dre-produced banger that became a cultural reset. With its instantly recognizable beat and catchy “Go shawty, it’s your birthday” hook, the song spent nine weeks at #1 and was later crowned Billboard’s #1 song of the 2000s. 

Fun fact: That famous birthday line? It was originally a placeholder in the demo. 50 freestyled the line just to feel out the rhythm, but everyone in the studio thought it was catchy, so they kept it in.

5. “Ms. Jackson” – OutKast (2000)

   
   Andre 3000’s apology to Erykah Badu’s mother became a heartfelt rap hit that climbed to #1 on the Billboard Hot 100. Its blend of quirky production and vulnerable lyrics earned it a Grammy. André 3000 had just gone through a breakup with Badu, with whom he had a child. The track became his way of processing the complicated emotions and effects on him. 

Fun fact: The title “Ms. Jackson” refers to Erykah’s real-life mom. In a twist, Badu’s mom reportedly loved the song despite its origins in real-life tension.

6. “Hot in Herre” – Nelly (2002)

   
   With Pharrell and Chad Hugo of The Neptunes on production, the song samples Chuck Brown’s “Bustin’ Loose” becoming an infectious summer anthem that defined early-2000s radio. It topped the Billboard Hot 100 for seven weeks and brought Nelly’s St. Louis swagger to the world.
   
   Fun fact: The title’s spelling — “herre” — was inspired by his local accent. Pharrell almost kept the beat for another project, but once Nelly heard it, he jumped on it.

6. “Through the Wire” – Kanye West (2003)

   
   Sampling Chaka Khan’s “Through the Fire,” it told his origin story in real time. It peaked at #15 and set the tone for his classic debut album The College Dropout.

Fun fact: Kanye recorded this track while recovering from a car accident, rapping with his jaw wired shut. 

8. “Drop It Like It’s Hot” – Snoop Dogg ft. Pharrell (2004)

   
   This minimalist, click-heavy production by The Neptunes paired perfectly with Snoop’s laid-back delivery. It gave him his first #1 single, and the slang phrase became a catchphrase. The term “drop it like it’s hot” had been around in the South, but this song mainstreamed it globally.

Fun fact: It was becoming Snoop’s first-ever chart-topping single on Billboard.

9. “Gold Digger” – Kanye West aka Ye ft. Jamie Foxx (2005)

   
   Kanye’s third entry on this list was a massive hit, spending 10 weeks at #1. Jamie Foxx channeled Ray Charles — fresh off his Oscar-winning performance — and gave the track its signature hook. It was clever, catchy, and offered sharp social commentary.

Fun fact: It debuted at #1 on the Billboard Hot 100 and was the longest-running #1 of 2005.

10. “Stan” – Eminem ft. Dido (2000)

    
    A dark narrative about a fan’s obsession, “Stan” blurred the lines between art and reality. Today, “stan” is used to describe intense fandom, all thanks to this chilling masterpiece.

Fun fact: It didn’t dominate the U.S. charts like others; however, its cultural impact cannot be denied. Eminem released 2 videos for this work.

Image Credits:

Nelly – Candice Ward / Contributor   |  Getty Images

50 Cent – Gilbert Flores / Contributor   |   Getty Images

Any other influential rap songs from 2000s you think should be on the list? Let us know in the comments